CCL19-producing fibroblasts promote tertiary lymphoid …
Tertiary lymphoid structures (TLSs) are ectopic lymphoid follicles that primarily consist of B cells, T cells, and myeloid cells. Recent studies have shown that the presence of TLSs is closely associated with better response to immunotherapy and overall survival (OS) across various solid tumors, such as melanoma, 6 soft-tissue sarcoma, 7 and breast cancer. 8 …
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Spatial dynamics of tertiary lymphoid aggregates in head …
Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) generally has a poor prognosis for patients with limited treatment options. While incorporating immune checkpoint inhibitors (ICIs) has now become the standard of care, the efficacy is variable, with only a subset of patients responding. The complexity of the tumor …
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Maturity and density of tertiary lymphoid structures …
Results: The pathological review identified TLSs in 95.1% of the tumors, lymphoid aggregates in 79.8%, primary follicles in 45.7%, and lymphoid aggregates in 95.1% of the cases. Based on Kaplan-Meier curves, the maturation and abundance of TLSs contributed to longer disease-free survival (DFS) and overall survival (OS).
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An immune cell map of human lung adenocarcinoma
A time-resolved immune cell atlas of human lung adenocarcinoma (LUAD) development from Liu et al. shows that Tfh, GC B cells, and dysfunctional CD8+ T cells form a tertiary lymphoid structure (TLS) that is associated with patient outcomes. Further functional studies establish an anti-tumoral role of the Tfh-dependent TLS mediated via IL-21-IL-21R signaling.
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Characteristics of tertiary lymphoid structures in primary …
The presence of intratumoral lymphoid aggregates with varying levels of organization (i.e., comprising or not a B-cell follicle and/or HEVs) has been described in patients affected by primary colorectal cancer, 20-24 breast carcinoma, 24-30 melanoma, 31-34 mucosal-associated lymphoid tissue (MALT) lymphoma, 35, 36 ovarian carcinoma, 24 and lung ...
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Lymphoid Aggregates in Endobronchial Biopsies from …
Processing of Bronchial Biopsies. ... Previous observations of lymphoid aggregates in human airways were made in studies of lung tissue obtained either at surgery or at post mortem. The aggregates in our study have similarities as well as differences to BALT as described in animal and human lung tissue (1, 2, 11, 12). The similarities are ...
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Helicobacter-Induced Chronic Active Lymphoid Aggregates …
Tertiary lymphoid tissue is a term describing ectopic lymphoid aggregates that accumulate during the process of chronic immune stimulation. Tertiary lymphoid organs exhibit characteristics usually associated with the secondary lymphoid organs (lymph nodes, Peyer's patches, and the spleen).
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Differentiating Benign From Malignant Bone …
We analyzed the staining patterns of the lymphoid aggregates with regard to the relative distribution patterns of the lymphoid populations. Histologic characteristics of the aggregates were retrospectively evaluated.
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colon biopsy reads fragments of colonic mucosa with small lymphoid
Colon biopsy reads fragments of colonic mucosa with small lymphoid aggregates and focal surface hyper plastic changes? what does this mean? 2 doctors weighed in across 2 answers. Dr. Ahmed Hasan answered. Must be biopsy of what looked like a polyp to the endoscopist. Biopsy is most likely pieces of hyperplastic polyp.
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Laboratory Evaluation of Bone Marrow
A thorough bone marrow evaluation is critical for diagnosing neoplastic and certain nonneoplastic hematopoietic conditions and monitoring patients undergoing bone marrow transplantation and chemotherapy. A comprehensive laboratory bone marrow examination includes a complete blood count (CBC) and analysis of the peripheral blood smear (PBS), …
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Lymphoid Follicles Are Generated in High-Grade Cervical …
Another type of lymphoid aggregate was commonly observed in cervical stroma of samples from HIV-positive women with high-grade SIL. These aggregates contained primarily CD8 + T cells, were interspersed with CD4 + T cells, and had few, if any, CD20 + or CD68 + cells (Figure 6) .
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(PDF) CD8+ T cells in human uterine endometrial lymphoid aggregates
Immunology 2001 102 434±440 CD8+ T cells in human uterine endometrial lymphoid aggregates: evidence for accumulation of cells by traf®cking G. R. YEAMAN, J. E. COLLINS, M. W. FANGER & C. R. WIRA Department of Immunology, Royal Free and University College Medical School, London, UK SUMMARY Lymphoid aggregates (LA) develop during the …
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Spatial dynamics of tertiary lymphoid aggregates in head …
Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) generally has a poor prognosis for patients with limited treatment options. While incorporating immune checkpoint inhibitors (ICIs) has now become the standard of care, the ...
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Tertiary Lymphoid Structures in Cancers: Prognostic Value, …
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A ...
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Anti-HBV Response to Toll-Like Receptor 7 Agonist GS-9620 …
This revealed that CD3 + T cells, CD8 + T cells and B cells formed lymphoid aggregates in the portal regions of the liver during the second GS-9620 treatment cycle (Fig. 4, Supplementary Figs. 9 and 10). These lymphoid aggregates had formed at most portal regions at the peak of antiviral response (Supplementary Fig. 11).
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The role of endometrial B cells in normal endometrium and …
Illustration of lymphoid aggregates in human endometrium. (A) The uterine lining, including the stratum functionalis and basalis (the endometrium), ... It is possible that LA GC-like B cells are implicated in this process by providing the site of plasma cell generation. However, visualization of GC-like B cells and associated cells necessary ...
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The murine meninges acquire lymphoid tissue properties …
The meningeal space is a critical brain structure providing immunosurveillance for the central nervous system (CNS), but the impact of infections on the meningeal immune landscape is far from being fully understood. The extracellular protozoan parasite Trypanosoma brucei, which causes human African …
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Spatial dynamics of tertiary lymphoid aggregates in head …
In this study, we analyzed two independently collected R/M HNSCC patient tissue cohorts to better understand the role of TLS in response to ICIs. Utilizing a multi-omics …
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CCL21 Expression Pattern of Human Secondary Lymphoid …
Four additional RA synovial samples selected for the presence of lymphoid aggregates and HEVs, two human tonsils, and one MLN were embedded in OCT and snap frozen in liquid nitrogen for comparative staining analysis with paraffin-embedded tissues. All procedures involving patient material were approved by the local ethics committee (code no ...
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[Lymphoid structures in the wall of the human esophagus …
Lymphoid aggregates in the wall of the human oesophagus have been studied in corpses of 107 persons died a sudden death and who had not any disease in the digestive organs and in the immune system (total plane preparations, slices stained with hematoxylin--eosin, azure-2-eosin and after van Gieson). …
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Tertiary lymphoid structures in anticancer immunity
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated.
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Of mice and lymphoid aggregates: modeling …
Here, we review key insights obtained from functional murine studies, discuss appropriate models that can be used to study cancer-associated TLS, and suggest guidelines on how to identify TLS and distinguish them from other …
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Hematopoietic and Lymphoid Tissues
Lymphoid aggregates may be seen in human marrow, where they increase in frequency with age or reactive conditions. Download: Download full-size image; Figure 19.3. Human bone marrow. ... Collection and Processing of Bone Marrow. Rodent bone marrow collection, usually from long bones and in some studies also or only from sternum, is almost ...
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Identification of a Novel Subpopulation of Human Cord …
CD94 Ag was detected on 30% of lymphoid progenitors on average, whereas the human neural-cell adhesion molecule CD56 was expressed at high levels by the majority of cells exposed to IL-15 (Fig. 9,A). In particular, >90% CD56-expressing cells resided in the CD56 bright fraction, whereas CD16, the low-affinity FcγRIII, could be detected on 10% ...
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Of mice and lymphoid aggregates: modeling tertiary …
Tertiary lymphoid structures (TLS) are ectopic immune aggregates that form at sites of chronic inflammation such as cancer (1). By definition, TLS are tight clusters of lymphoid cells that can organize in distinct B and T cell compartments, thus resembling secondary lymphoid organs.
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Tertiary lymphoid structures and their therapeutic …
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells such as B cells and T cells in non-lymphoid …
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Tumor-Associated Tertiary Lymphoid Structures: From Basic …
In human studies, an in-depth analysis of the organization and interactions of tumor-infiltrating immune cells has revealed the presence of an ectopic lymphoid organization …
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CD8+ T cells in human uterine endometrial lymphoid aggregates …
Lymphoid aggregates (LA) develop during the proliferative phase of the menstrual cycle in the human uterine endometrium (EM). They contain mostly CD8+ T cells and B cells. As these LA are absent immediately following menses, they may arise by division of cells resident in the EM, or by division of a …
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Lymphoid aggregates (benign)
Benign lymphoid aggregates with a germinal center on the bone marrow core biopsy will be CD10+, BCL6+, BCL2-. CD10, BCL6, HGAL and LMO2 are germinal center …
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Unique CD8 + T cell‐rich lymphoid aggregates in …
to be present in low but measurable numbers in the human uterus [3, 7, 15, 19, 20]. The number of T cells relative to other lymphoid cells does not increase significantly dur-ing the menstrual cycle. However, the relative distribution of T cells does change over the course of the menstrual cy-cle. Discrete lymphoid follicles, or lymphoid ...
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